Neuroimaging studies of different cognitive profiles in Parkinson's disease.
Identifieur interne : 001170 ( Main/Exploration ); précédent : 001169; suivant : 001171Neuroimaging studies of different cognitive profiles in Parkinson's disease.
Auteurs : Oury Monchi [Canada] ; Clotilde Degroot ; Beatriz Mejia-Constain ; Marie-Andrée BruneauSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Cognition Disorders, Parkinson Disease.
- epidemiology : Cognition Disorders, Parkinson Disease.
- methods : Neuroimaging.
- psychology : Cognition Disorders, Parkinson Disease.
- Animals, Humans.
Abstract
It is now clear that cognitive deficits exist even early in Parkinson's disease, having a significant impact on daily activities. However, the nature and the neural origins of cognitive dysfunction in PD are still under debate. Furthermore, a great heterogeneity seems to exist with respect to the cognitive profiles found in patients at the early stages of the disease, and these initial differences are likely predictive of distinct outcomes regarding the later occurrence of dementia. These include the early presence of Mild Cognitive Impairments, the nature and number of domains affected, as well as the occurrence of depression or apathy. Here, we will review studies involving anatomical and functional neuroimaging, and neuropsychological evaluation that have attempted to address these issues. Recommendations for future work will also be discussed.
DOI: 10.1016/S1353-8020(11)70025-6
PubMed: 22166462
Affiliations:
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However, the nature and the neural origins of cognitive dysfunction in PD are still under debate. Furthermore, a great heterogeneity seems to exist with respect to the cognitive profiles found in patients at the early stages of the disease, and these initial differences are likely predictive of distinct outcomes regarding the later occurrence of dementia. These include the early presence of Mild Cognitive Impairments, the nature and number of domains affected, as well as the occurrence of depression or apathy. Here, we will review studies involving anatomical and functional neuroimaging, and neuropsychological evaluation that have attempted to address these issues. Recommendations for future work will also be discussed.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bruneau, Marie Andree" sort="Bruneau, Marie Andree" uniqKey="Bruneau M" first="Marie-Andrée" last="Bruneau">Marie-Andrée Bruneau</name><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name></noCountry><country name="Canada"><noRegion><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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